Key takeaways

If there is a word that personifies modern life, it would be: ‘busy’. Busy is something we pride ourselves on; no matter the arena. To be the first to arrive at work, and the last to leave is glorified. A mum who manages to hold the family together, while doing all the home-life stuff, including multiple extra-curricular activities for the kids, while putting herself last, is said to be exhausted a ‘Super-Mum’; doubly so if she is single. The cost that is almost always paid for busyness is sleep.

On a deep level, we know that sleep is the ultimate expression of rest and recovery; and we are tired. So why don’t we sleep more?

I can almost hear the psychological defences mounting; the excuses; the justifications; the rationalisations. What it all comes down to, though, is this: we don’t prioritise sleep; because we’re busy.

‘I’ll sleep when I’m dead.’

An all too poignant quote, as opting out of sleep, will make you dead; literally.

The why of sleep

We have long known that no sleep can lead to myriad of serious health conditions, and studies have shown that between 11-32 days of no sleep may even kill you (1). What we didn’t know is why, but a recent discovery brings new knowledge to light. Bear with me, and I’ll get to it, there are just a few things you need to understand first.

The human body possesses a series of blood vessels that are like water pipes; they carry good stuff around the body. In parallel to the vascular system, is the lesser-known lymphatic system; a system of sewerage pipes – if you like – that transport waste. The human brain makes up around 2% of our total body weight (2), and yet is responsible for roughly 60% of glucose usage in a resting state. Interestingly, despite being so much more metabolically active than any other area of the body, the brain does not have a lymphatic system.

How is it that our most vital of organs generate so much metabolic waste, and yet has no system to remove it? The answer, of course, is that it does; the previously elusive, and yet elegant ‘glymphatic system’.

While you sleep, your neurons compress in on themselves, like sponges, to squeeze metabolic and other toxins into a newly created paracellular space in between the now shrunken spongey neurons. This specific function occurs almost exclusively while you sleep.

Said another way: sleep is when your brain detoxes. No sleep means no removal of metabolic gunk. A critical build-up of neuronal waste can result in death.

The why of sleep – it is important

Most people don’t die for lack of sleep, but these things are never as simple as black and white. 28 hours or more of no sleep results in cognitive impairment to the equivalent of a Blood Alcohol Concentration of 0.10%. Just a week of fewer than six hours of sleep a night results in the same cognitive impairment.

Said another way: when you skip out on sleep, despite thinking that you are operating fine, your brain is gunked-up to the point where you cognitively function as if you are drunk; just without the fun ‘buzz’.

Probably at times, you have skipped out on sleep, and your own personal experience suggests that after a few days of extra sleep, you are back to normal. We can ‘catch up’ on sleep… right? Well yes, and no… maybe. On this, I have no studies to support my thinking, intuitively compelling as it may be.

If an accumulation of waste in your brain is what causes under-functioning, then with extra sleep, you should be able to work through a ‘back-log’, clear it all, and hence have reset your brain and ‘caught up’. My suspicion, however, is that you will never completely ‘catch up’ on the neuronal damage already sustained through increased time in contact with metabolic and other waste.

While you can perhaps prohibit further damage by ‘catching up’, you can’t entirely undo the damage already done. We know that there are elements of health that can be brought back into alignment with extra sleep like cortisol, daytime sleepiness and fatigue. Still, there are certainly critical elements of health which cannot be improved by playing catch up, including performance deficits (3).

The physical restorative effects of sleep are well understood, as is the role of memory consolidation. Suboptimal sleep has been linked with type 2 diabetes, weight gain, hypertension and cardiac events, just to name a few.

We, of the modern world, like to burn the candle at both ends; soon enough we must pay the piper. I believe that busyness, and the resulting: stress, lack of sleep, poor food habits, and inattention to diet, are the root of modern chronic disease. Don’t make the mistake of thinking you can achieve your optimal health by paying attention only to the ‘doing’ things, like diet and exercise.

This is your wake-up call. Get your full sleep quota.


1: Everson CA, Bergmann BM, Rechtschaffen A. Sleep deprivation in the rat: III.

2 Marcus E. Raichle,  10237–10239, doi: 10.1073/pnas.172399499

3 Am J Physiol Endocrinol Metab. 2013 Oct 1;305(7):E890-6. doi: 10.1152/ajpendo.00301.2013. Epub 2013 Aug 13. Effects of recovery sleep after one work week of mild sleep restriction on interleukin-6 and cortisol secretion and daytime sleepiness and performance.

Discover a new way to get your health back

Discover more

jabe brown functional medicine practitioner wearing blue shirt standing smiling
Jabe Brown
Jabe holds a Bachelor of Health Science (Naturopathy) and a Masters in Science, Human Nutrition, and Functional Medicine. As the founder of Melbourne Functional Medicine, Jabe's focus in on delivering clinical excellence as well as growth for the business.
Read full bio
Have something to add, or want to ask
Jabe Brown
something? Join the conversation in the comments below and we'd be delighted to chat.
Have something to add, or want to ask
something? Join the conversation in the comments below and we'd be delighted to chat.
{ "datePublished": "Mar 21, 2023" }